The effect of number of mating on longevity and fecundity of the predatory mite Euseius scutalis Athias-henriot was studied under laboratory conditions (at 25±1 ºC, 60 ± 5 % RH and 16: 8 L:D). Newly emerged adult females (less than 24 h) were held individually in a 9 cm arena. A male (less than 24 h) remained with a female for limited periods of time or continuously. Four treatments were designed: virgin females, single mated females, Multiple mated females (female had access to a male every five days), Multiple mated females (female had continuous access to a male). Mating was necessary for oviposition. Virgin females lived the longest (25 days). However, no significant differences were found among longevity of mated females (12- 15). Similarly, no significant differences were detected among fecundity of females with different numbers of mating (18- 22 eggs). Sex ratio was significantly female-biased in progeny of single mated females and Multiple mated females with periodic access to male. However, no significant difference was found in sex ratio of progeny of Multiple mated females with continuous access to male.

Purpose: To report a patient with MEWDS.Patient and findings: A 65-year-old man presented with sudden decrease of vision in his right eye. On ophthalmoscopy of the involved eye, numerous small discrete white lesions were detected superficially and deep in the retina around the disc and macula. On visual field examination, enlargement of the blind spot was detected. Fluorescein angiography was unremarkable. On electroretinography, the a-wave was decreased minimally. The patient was followed and after 2 months, significant improvement of visual acuity and visual field was observed.Conclusion: MEWDS is a rare intraocular inflammatory disease of unknown etiology and in contrast to our patient, more frequent in females. The natural course is generally benign with spontaneous disappearance of the lesions and improvement of vision in 6 to 8 weeks.

In this paper, we develop a new mathematical model that integrates layout configuration and production planning in the design of dynamic distributed layouts. The model incorporates a number of important manufacturing attributes such as demand fluctuation, system reconfiguration, lot splitting, work load balancing, alternative routings, machine capability and tooling requirements. In addition, the model allows several cost elements to be optimized in an integrated manner. These costs are associated with material handling, machine relocation, setup, inventory carrying, in-house production and subcontracting needs. Numerical examples of different sizes are presented to illustrate the nature of the developed model and shed light on several managerial insights.

Purpose: To report a case of severe macular edema following the taking of fingolimod in Multiple sclerosis.Case Report: A 34-year-old woman with a long history of relapsing-remitting Multiple sclerosis presented complaining of blurred vision in the left eye that started 1 week before the presentation. She had been taking fingolimod for 4 months. She was not diabetic and had no history of uveitis but reported an episode of retrobulbar optic neuritis in both eyes. The initial ophthalmic examination, which was performed 2 weeks before initiating fingolimod, revealed a best corrected visual acuity (BCVA) of 20.25 OU and no ocular abnormalities. Upon the recent presentation, BCVA was 20.25 OD and 20.70 OS and there was no afferentpapillary defect. The examination of anterior segment and anterior vitreous was unremarkable. Retinal examination of the left eye revealed cystoid macular edema with no other inflammatory signs or vascular changes. The findings of spectral domain optical coherence tomography (SD-OCT) were compatible with macular edema and indicated that the central macular thickness (CMT) was 605 microns. Fingolimod was discontinued and sinarolac was started three times daily. After 6 weeks, BCVA was 20.25 OD and 20.30 OS.Macular edema was resolved clinically and SD-OCT exhibited a significant reduction in macular edema with a CMT of 277 microns.Conclusion: Fingolimod-associated macular edema is a benign complication of the drug used for Multiple sclerosis and. This complication responds well to the drug discontinuation and topical non-steroidal antiinflammatory administration.

Introduction: Myocardial bridging is a congenital condition in which a segment of a major epicardial coronary artery has an intra myocardial route. Myocardial bridging is usually confined to a single vessel and is typically the mid segment of the left anterior descending artery. Bridging may be associated with chest pain, myocardial infarction, and sudden cardiac death, or usually asymptomatic.Case Report: A 59 year-old women with diabetes mellitus and hypertension presented with dyspnea and chest pain on exercise. Physical exam, electrocardiography and echocardiography were intact. In angiography, we found severe stenosis of left main coronary artery and severe stenosis of three coronary artery (Three Vessel Disease) as well as Multiple myocardial bridges at the end of right coronary artery.Conclusion: Myocardial bridging is a rave condition, however, it be considered in patients facing recurrent chest pain, it has severe complication such as sudden cardiac death.

Introduction: Uterine fibroids (leiomyomas) are the most common benign tumors of the female reproductive system, affecting approximately 20% of women of reproductive age. These tumors can be single or Multiple, and depending on their size and location, they may be asymptomatic or present with symptoms such as abnormal uterine bleeding, pelvic pain, infertility, or pressure effects on adjacent organs. In symptomatic cases, especially when fertility preservation is desired, accurate diagnosis and individualized treatment planning are essential. Case Presentation: A 42-year-old woman with a history of two cesarean deliveries and symptoms of abnormal uterine bleeding including prolonged heavy menstruation with clot passage was referred to Sarem Women’s Hospital. Imaging revealed Multiple myomas of varying types and locations, including a large submucosal fibroid extending into the endometrial cavity, intramural myomas in both anterior and posterior uterine walls, and hypoechoic intracavitary structures suggestive of additional myomas. Nabothian cysts and small endometrial polyps were also identified. The final diagnosis was intracavitary myoma, and the patient underwent hysteroscopic myomectomy and polypectomy. Conclusion: The successful management of this patient using minimally invasive hysteroscopic surgery highlights the importance of precise evaluation of fibroid type, size, and location in determining the most appropriate treatment approach. Advanced imaging techniques, such as Saline Infusion Sonohysterography (SIS), combined with comprehensive clinical assessment, play a pivotal role in surgical planning, particularly for women seeking to preserve their uterus and fertility potential.

Background: microRNAs are non-coding RNAs that modulate different types of cellular processes like differentiation and cell death. Hitherto several studies have been done to determine the expression profile of microRNAs in patients with Multiple sclerosis (MS) to obtain appropriate biomarkers. In previous studies, it was found that miR-145 was over-expressed. This up-regulation was in patients who did not start taking medicine. Therefore, in this study we assessed the effect of beta interferon on the expression of this microRNA in patients with Multiple sclerosis.Methods: We evaluated the expression pattern of miR-145 in 15 patients who did not start taking medicine and called treatment naive، in 15 patients who were under treatment and also 15 healthy people using real-time polymerase chain reaction method.Findings: The expression level of miR-145 in treatment naive patients was 3.9 fold of healthy people (P=0.005), whereas expression level of this microRNA between healthy people and under treatment patients was not significantly different.Conclusion: Down-regulation of miR-145 in under-treatment patients to the extent of healthy people suggests that probably, this microRNA could be used as predictive biomarker.